Our innovations redefine how scientists see the invisible.
The Lew Lab integrates advanced optical design, computation, and biophysical chemistry to create multidimensional optical imaging systems that transcend conventional limits, thereby capturing molecular positions, orientations, chemical environments, and biomolecular interactions in unprecedented detail. The team collaborates across biochemistry, physics, and engineering to translate fundamental discoveries in nanoscale sensing into imaging technologies that accelerate breakthroughs in biology, medicine, and materials science.
We stand up for science.
The Lew Lab is a team of inventors, thinkers, and problem solvers working at the intersection of science and technology.
Creating impactful technology is our passion.
Lab news
Upcoming talks
October 26, 2026: Matt
will give an invited talk in the “Super-Resolved Spectroscopy: Physical Phenomena in Space and
Time” session at the Midwest Regional ACS
Meeting at Kansas State University. 1:30 PM, Room 206 (second floor).
October 30,
2026: Join the lab at the 2026
Student-led SPECTRA Conference. Matt will give an invited talk, and the group will present posters on our latest research.
Alex's undergraduate research project, “Optimal Excitation Polarization Schemes to Boost the Precision
of Single-Molecule Orientation Imaging,” is now online in Biomedical Optics Express.
Congratulations!
- Update: Alex's work appears in McKelvey Engineering News: “How
light can reveal the hidden orientation of a single molecule”
Yiyang's and
Yuanxin's review, “Single Fluorogens and
Orientation-Localization Microscopy for Quantifying Chemical and Biomolecular Dynamics at the
Nanoscale,” is now online in Accounts of Chemical Research. Congratulations!
Update: Their article is featured on the cover of the August 18, 2026 issue of Accounts of Chemical
Research!
Matt has been promoted to Senior Member of
SPIE. Congratulations!
The group trekked to the
University of Illinois Urbana-Champaign for the 7th Midwest Single Molecule
Workshop. We presented 5 posters, and Matt gave an invited talk.
Our collaborator Emil Gillett and colleagues in the Landes Research Group have published “Fused deep-learning enables 6D single-molecule localization in polarization-resolved microscopy” in Methods and Applications of Fluorescence. Happy reading!