Washington University in St Louis

The Preston M. Green Department of
Electrical & Systems Engineering

Our innovations redefine how scientists see the invisible.

Lew Lab group photo

The Lew Lab integrates advanced optical design, computation, and biophysical chemistry to create multidimensional optical imaging systems that transcend conventional limits, thereby capturing molecular positions, orientations, chemical environments, and biomolecular interactions in unprecedented detail. The team collaborates across biochemistry, physics, and engineering to translate fundamental discoveries in nanoscale sensing into imaging technologies that accelerate breakthroughs in biology, medicine, and materials science.

We stand up for science.

We stand up for science
Flyer adapted from Stand Up for Science. Learn about how scientific research improves our health, our society, and our economy.

The Lew Lab is a team of inventors, thinkers, and problem solvers working at the intersection of science and technology.

Creating impactful technology is our passion.

Lab news

SPIE Senior Member logoMatt has been promoted to Senior Member of SPIE. Congratulations!

7th Midwest Single Molecule Workshop, July 22-24, 2026The group trekked to the University of Illinois Urbana-Champaign for the 7th Midwest Single Molecule Workshop. We presented 5 posters, and Matt gave an invited talk. The Lew Lab presents posters at the 7th Midwest Single Molecule Workshop

GRC logoMatt gave an invited talk, “Multidimensional Single-Molecule Imaging: Linking Rotational Dynamics to Biological Function,” at the Single-Molecule Approaches to Biology Gordon Research Conference in Les Diablerets, Switzerland.

Alex's portrait Alex received the Professional Development Award from the Department of Electrical and Systems Engineering! Alex was recognized at the 2026 McKelvey School of Engineering Engineers' Honors Ceremony. Congratulations, Alex!

Brian presents a student talk at the 2026 ISP retreat Brian gave a student talk at the 2026 Imaging Science Pathway retreat! Thanks for doing a great job representing the lab, Brian!

Cynthia's portrait The lab congratulates and extends a warm welcome to Cynthia Cheng, who has received a Summer Undergraduate Research Guided Experience (SURGE) award! She will join us this summer to work on adaptive microscope design.

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