Our innovations redefine how scientists see the invisible.
The Lew Lab integrates advanced optical design, computation, and biophysical chemistry to create multidimensional optical imaging systems that transcend conventional limits, thereby capturing molecular positions, orientations, chemical environments, and biomolecular interactions in unprecedented detail. The team collaborates across biochemistry, physics, and engineering to translate fundamental discoveries in nanoscale sensing into imaging technologies that accelerate breakthroughs in biology, medicine, and materials science.
We stand up for science.
The Lew Lab is a team of inventors, thinkers, and problem solvers working at the intersection of science and technology.
Creating impactful technology is our passion.
Lab news
Upcoming talks
June 28-July 3, 2026: Matt will give an invited talk at the Single-Molecule
Approaches to Biology Gordon Research Conference at the Les Diablerets Conference Center in
Les Diablerets, Switzerland. He will speak on “Multidimensional Single-Molecule Imaging: Linking
Rotational Dynamics to Biological Function.”
July 22-24, 2026: Matt
will give an invited talk at the 7th
Midwest Single Molecule Workshop at the University of Illinois Urbana-Champaign.
Brian gave a student talk at the 2026
Imaging Science Pathway retreat! Thanks for doing a great job representing the lab, Brian!
The lab congratulates and extends a warm welcome to Cynthia Cheng, who has received a Summer Undergraduate Research Guided Experience (SURGE) award! She will join us this summer to work on adaptive microscope design.
Matt's Spotlight on Optics commentary on
“Surface orientation ambiguity for single molecules at
dielectric interfaces” from Dey et al. is now online. Check it out!
Yuanxin gave a talk in
the “Single Molecule Spectroscopy and Superresolution Imaging XIX” session at SPIE Photonics
West. He spoke on “Sensing
negative cone rotational diffusion of dipole-like emitters.” Read about it here.
Our collaborative work with the Pappu lab, “Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases”, is now online in Cell. Congratulations, Min Kyung!