We build novel imaging technologies
The Lew Lab builds advanced imaging systems to study biological and chemical systems at the nanoscale. Our technology leverages innovations in applied optics, signal and image processing, design optimization, and physical chemistry. We partner with scientists and engineers across all disciplines to develop technologies to solve unmet needs in science, medicine, and society.
We stand up for science
The Lew Lab is a team of inventors, thinkers, and problem solvers working at the intersection of science and technology.
Creating impactful technology is our passion
Lab news
Matt's Spotlight on Optics commentary on
“Surface orientation ambiguity for single molecules at
dielectric interfaces” from Dey et al. is now online. Check it out!
Yuanxin gave a talk in
the “Single Molecule Spectroscopy and Superresolution Imaging XIX” session at SPIE Photonics
West. He spoke on “Sensing
negative cone rotational diffusion of dipole-like emitters.”
Our collaborative work with the Pappu lab, “Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases”, is now online in Cell. Congratulations, Min Kyung!
Matt gave a talk in
the “Advances in
Single-Molecule and Single-Particle Imaging Symposium” at Pacifchem 2025. He spoke on
“Single-fluorogen orientation-localization microscopy: fundamental limits, new developments,
and applications.”
Matt has been elected
a Fellow Member of Optica by the Society’s Board of Directors. He is being recognized “For
pioneering contributions to super-resolution microscopy, single-molecule imaging, and the development of
innovative nanoscale sensing techniques.” Matt is deeply honored by the recognition, and extends his
special thanks to all Lew Lab members, collaborators, and mentors, past and present! [McKelvey Engineering
News]
Our correction to “Single-molecule orientation localization microscopy I: fundamental limits” is now online in JOSA A.
Congratulations, Yiyang and Yuanxin, on receiving a second-place poster prize at the annual WashU SPECTRA student-led conference!