Welcome to the Lew Lab archives! Here you'll find noteworthy milestones and past lab news. See how far the lab has come.
2024
The lab welcomes Erik Lindeman, who received a Caltech Summer Undergraduate Research Fellowship
to visit us for a summer project. We're excited to have you!
The lab welcomes Sam Kang, who has received a 2024 Summer Undergraduate Research Award to work
with us. Congratulations!
The Lew Lab welcomed Tingting back to campus for the first-ever McKelvey PhD Hooding
Ceremony. She also received an Outstanding Dissertation Award from the Imaging Science
Doctoral Program. Congratulations, Tingting!
The lab welcomes Suraj Deepak Khochare, who is pursuing a PhD in Imaging Science.
Jasmine was recognized at the 2024 McKelvey
Engineers' Honors Ceremony with the David H. Levy Outstanding Senior Award.
Congratulations!
Weiyan's extensive study on using orientation imaging to reveal the
architectures of peptide self-assemblies is now online in
ACS Nano!
- Read it here: “Resolving the Nanoscale
Structure of β-Sheet Peptide Self-Assemblies Using Single-Molecule Orientation–Localization
Microscopy”
- “Imaging
technique shows new details of peptide structures” - The Source - Washington University
- Update: Weiyan's article is featured as a cover of Volume 18,
Issue 12 of
ACS Nano!
Tingting's review chapter on dipole-spread function engineering for
six-dimensional imaging, part of a new book, Coded Optical Imaging, is now
online!
Read it here: “Dipole-Spread
Function Engineering for Six-Dimensional Super-Resolution Microscopy”
Congratulations to our close colleague Dr. Matt King in
the Pappu lab on his study of pH gradients within the
nucleolus, now appearing in Cell!
- Read it here: “Macromolecular
condensation organizes nucleolar sub-phases to set up a pH gradient”
- News coverage: The
Source - Washington University, EurekAlert!
Matt gave an invited
talk in the “Quantum Sensing
and Information
Processing for Biomedical Applications”
session at the APS March Meeting in Minneapolis, entitled “6D Single-Molecule
Orientation-Localization Microscopy: Fundamental Limits for Visualizing the Dynamic
Organization of Biomolecules.”
Congratulations to Prof. Jin Lu, now at the National Center for
Nanoscience, whose work on single-molecule electrochemical imaging is now online in
Chemical Science!
- Read it here: “Single-Molecule
Electrochemical Imaging Resolves the Midpoint Potentials of Individual Fluorophores on
Nanoporous Antimony-Doped Tin Oxide”
- Update: Jin's article is now featured as an inside cover in Volume 15,
Issue 6 of
Chem. Sci.!
Matt
gave
an invited talk, “6D
single-fluorogen orientation-localization microscopy for elucidating the architecture of
beta-sheet assemblies and biomolecular condensates,” in the “High-Speed
Biomedical Imaging and Spectroscopy IX”
conference at Photonics West in San Francisco. [Open
Scholarship, Article]
Oumeng's news article, “Single-molecule
orientation-localization microscopy,” is now online in Imaging &
Microscopy.
2023
Tingting successfully
defended her thesis, “Information-Rich
6D Single-Molecule Imaging Using Optimization,” on Monday, November 20, at 1 PM in Green
Hall's Rodin Auditorium. Congratulations and we will miss you, Tingting!
We hiked together and celebrated Tingting's many contributions to the group. After graduating,
she will be a Senior Optical Metrology Engineer at Metalenz in Boston, MA. Thank you for
bringing advanced computation and biomolecular condensates to the lab!
Brian and Jasmine presented their research at the 2nd annual SPECTRA student-led conference. Both the talks
and poster session had superb attendance. Thanks to the wonderful 2023 officers for bringing
together the WashU optics community!
Matt presented “Single-fluorogen imaging reveals the nanoscale structure of beta-sheet
assemblies and biomolecular condensates” in the “Single-molecule Dynamics in Complex
Chemical and Biological Systems” session at SERMACS
2023.
“Capturing images of molecules with a new level of resolution: An interview with Prof. Matthew Lew” was published in Wiley Analytical Science magazine.
Congratulations to Weiyan, who won a poster award at the Chemical Imaging GRC 2023!
Our lab has received a five-year $2 million Maximizing Investigators’ Research Award (MIRA) from the National Institutes of Health (NIH) to develop adaptive six-dimensional microscopy. Congrats, all!
Congratulations, Tingting, on receiving a 2023 Outstanding Research Award from the Imaging
Science Doctoral Program!
Congratulations, Jasmine, on receiving a 2023 Summer Undergraduate Research Award!
Two outstanding undergraduates have received awards this year: Brian with the Rick Grodsky Award
for Technical Achievement and the David H. Levy Outstanding Senior Award, and Jasmine with the
Russel R. Pfeiffer Outstanding Junior Award! Both were recognized at the 2023 McKelvey Engineers' Honors
Ceremony. Congratulations, Brian and Jasmine!
Matt has received a 2023
Outstanding Faculty Award from the Graduate Student
Senate. The awardees were recognized at a
ceremony organized by the GSS. Thank you, students, for this honor!
The Lew Lab presented several exciting posters and talks at BPS 2023 in San Diego:
- Congratulations to Tingting, who has received a 2023 Travel Award to present at the Annual
Meeting!
- Congratulations to Weiyan, whose submission to the Biophysical Society Art of Science Image
Contest was selected as one of ten finalists! Her art was displayed in the Exhibit Hall during
the meeting.
- Weiyan presented “Single-Molecule Orientation-Localization Microscopy Resolves the
Nanoscale Organization
of Self-Assembled Peptides,” Poster 627-Pos / B448 in Optical Microscopy and
Superresolution Imaging I on Sunday, Feb 19
[Abstract]
- Brian presented “Single-Molecule Orientation-Localization Microscopy Resolves How
Amyloidophilic Dye
Orientations are Correlated with Amyloid Fiber Growth and Disruption,” Poster 1339-Pos /
B468 in Optical Microscopy and Superresolution Imaging II on Monday, Feb 20 [Abstract]
- Matt presented “A Multi-View Reflector Microscope Visualizes Six-Dimensional
Single-Molecule
Translational And Rotational Dynamics With Isotropic Nanoscale Resolution,” Poster
1351-Pos / B480 in Optical Microscopy and Superresolution Imaging II on Monday, Feb
20 [Abstract]
- Tingting presented “Mapping Inhomogeneous Network Structures within Biomolecular
Condensate using
Single-Molecule Imaging and Tracking of Fluorogenic Probes,” Platform Talk
1437-Plat in Condensates: Physical Properties and Modeling II on Tuesday,
Feb 21 at 9:15 AM [Abstract]
2022
Congratulations to Oumeng and our collaborators in the Vahey Lab in WashU Biomedical Engineering on
publishing a new microscope architecture for 6D single-molecule super-resolution imaging in
Nature Photonics! The multi-view reflector (MVR) microscope achieves nearly isotropic
10.9 nm precision in 3D over a 1.5 μm depth range and measures the 3D orientation of single
molecules with 2.0° precision.
- “Six-dimensional single-molecule imaging with isotropic resolution using a multi-view
reflector microscope,” Nat. Photon. 17, 179 (2023). [The
Source - Washington University, Open Scholarship, Article, Data, Summary
PDF]
- “Telescope-inspired
microscope sees molecules in 6D” in the Source.
Tingting's collaborative work with Peng and Asheq on using deep-learning for 5D imaging (2D
position and 3D orientation estimation) of single molecules is now online in Optics
Express. Congratulations!
- “Deep-SMOLM: deep learning resolves the 3D orientations and 2D positions of overlapping
single molecules with optimal nanoscale resolution,” Opt. Express 30, 36761
(2022). [McKelvey
Engineering News, Article, Code, Data, Video abstract]
- “Machine
learning generates pictures of proteins in 5D” in McKelvey Engineering News.
Matt led the “Single Molecules and Phase” session at the 65th Welch Conference on
Chemical Research, “Molecules and Sculpted Light.” W.
E. Moerner chaired the conference, which featured awesome science and timely addresses
from Peter Hotez and Carolyn R. Bertozzi.
The Lew Lab is thrilled to be part of the new Center
for Biomolecular Condensates in the McKelvey School of Engineering. The inaugural symposium was inspirational and great
fun! [McKelvey
Engineering News]
James's theoretical exploration of how to design microscopes optimized for resolving closely
spaced objects in 3D is now online in Optics Express. Congratulations!
- “Towards optimal point spread function design for resolving closely spaced emitters in
three dimensions,” Opt. Express 30, 37154 (2022). [Article]
- James's paper has been highlighted as an Editor's Pick!
Dr. Meikun Shen, formerly in the Sadtler group, has published a study on how ascorbic acid
enhances water oxidation activity on the surfaces of tungsten oxide nanowires. It appears in
Nano Lett. Congratulations!
“In Situ Imaging of Catalytic Reactions on Tungsten Oxide Nanowires Connects
Surface–Ligand Redox Chemistry with Photocatalytic Activity” [Article]
Matt is spotlighted as a STEM expert in the summer 2022 issue of the Saint Louis Science
Center's NewScience magazine. He discusses the incredible potential of computational
imaging in “Can a Computer Help Make a Better Camera?”.
Read: Magazine
version, Web/mobile
version, PDF [51.8 MB]
Congratulations, Oumeng, on being featured as an outstanding graduate by the McKelvey School of Engineering!
Congratulations, Jasmine, on receiving a 2022 Summer Undergraduate Research Award!
Tingting's work on engineering new dipole-spread functions (DSFs) for imaging single molecules
in 6 dimensions (3D position plus 3D orientation) is now online in Optica.
Congratulations!
- “Dipole-spread-function engineering for simultaneously measuring the 3D orientations and
3D positions of fluorescent molecules,” Optica 9, 505 (2022). [Article, Data, Video abstract]
- “Lew
lab sheds new light on cell membranes” - The Source
The lab welcomes Yiyang Chen and Yuanxin Qiu, both in the Imaging Science PhD program. It's
great to have you!
Matt give another invited colloquium, “Single-Molecule Orientation Localization Microscopy: Visualizing Molecular Organization at the Nanoscale”, at the Department of Physics & Astronomy at San Francisco State University.
Matt give an invited talk, “Single-Molecule Orientation Localization Microscopy: Visualizing Molecular Organization at the Nanoscale”, at the MIT Laser Biomedical Research Center's Modern Optics and Spectroscopy Seminar.
Congratulations to Dr. Hesam Mazidi, whose patent on using Wasserstein-induced flux to certify localization accuracy has been granted!
Tingting presented “pixOL: pixel-wise dipole-spread function engineering for simultaneously measuring the 3D orientation and 3D location of dipole-like emitters” at Focus on Microscopy 2022.
Congratulations, Dr. Oumeng Zhang, on successfully defending his PhD
dissertation!
We congratulate Oumeng on receiving the Department of Electrical and Systems Engineering's Outstanding Doctoral Dissertation Award! Thank you for your outstanding contributions to the technology and culture of innovation in our lab!
We also congratulate Brian on receiving the Russell R. Pfeiffer Outstanding Junior Award! It is well-deserved!
The Washington University in St. Louis Board of Trustees has promoted Matt to the rank of Associate Professor with tenure. Onward and upward!
Congratulations Tingting on receiving a second-place poster award at the 2022
Imaging Sciences Pathway Retreat!
The Lew Lab presented several posters at BPS
2022 in San Francisco:
- “Accurate Superresolution Microscopy of the 3D Orientations and 3D Locations of Single
Molecules within Lipid Membranes and Biomolecular Condensates,” Poster 694-Pos / B518 in
Optical Microscopy and Superresolution Imaging I [Abstract]
- “Visualizing the Nanoscale Architecture of Amyloid Aggregates using Amyloidophilic
Probes and a Polarized Vortex Microscope,” Poster 693-Pos / B517 in Optical Microscopy and
Superresolution Imaging I [Abstract]
- “Mapping the Chemical Composition and Nanoscale Structure of Lipid Membranes using
Polarized Fluorescence from Single Molecules,” Poster 2353-Pos / B183 in Membrane
Structure II [Abstract]
Today, the Lew Lab celebrates the science and mentorship of W. E. Moerner and the publication of a Festschrift
issue of the Journal of Physical Chemistry dedicated to him. Thank you, W. E.,
for your pioneering work and leadership that continues to inspire generations of scientists and
engineers!
Read:
- Tribute
to W. E. Moerner
- Autobiography
of W. E. Moerner
- About
the cover
- Our contribution to the Festschrift: “Single-Molecule Localization Microscopy of
3D Orientation and Anisotropic Wobble Using a Polarized Vortex Point Spread
Function”
Welcome, Wentao, to the Lew Lab!
Oumeng's study of using radially and azimuthally polarized fluorescence to measure the
translational and rotational dynamics of Nile red in lipid bilayers is now online in Nano
Letters. Congratulations!
- “Resolving the Three-Dimensional Rotational and Translational Dynamics of Single
Molecules Using Radially and Azimuthally Polarized Fluorescence,” Nano Lett.
22, 1024 (2022). [Open Scholarship, Article, Summary PDF]
- “Lew
lab sheds new light on cell membranes” - The Source
2021
Tianben's postdoctoral work on developing the polarized vortex PSF for imaging the 3D
orientations and 3D wobble of single molecules is now online in J. Phys. Chem. B.
Congratulations!
“Single-Molecule Localization Microscopy of 3D Orientation and Anisotropic Wobble Using a
Polarized Vortex Point Spread Function,” J. Phys. Chem. B 125, 12718 (2021).
[The
Source - Washington University, EurekAlert!, Open
Scholarship, Article, Summary PDF
Update: Tianben's art has been selected as a supplemental cover for volume 125, issue 46 of J. Phys. Chem. B!
Matt gave a talk about single-molecule imaging of electron transfer pathways at NA-ISMET 2021 in Los Angeles,
CA. There were many fascinating talks covering all aspects of microbial electrochemistry and
technology. Thanks to Moh and his group for organizing
and hosting!
Matt gave an invited talk in the “Single-Molecule Approaches to Chemistry and
Biology” session at SERMACS 2021 in Birmingham,
AL. It was great to see such fantastic single-molecule studies in person! Thanks Kevin for organizing!
We got together for a beautiful hike and celebrated Tianben's many contributions to the group.
We wish him well as a new researcher at Hitachi, Ltd. in Japan. Thank you for inspiring us with
new optical technologies and studies on catalysis and amyloid imaging!
Tianben and Tingting gave platform presentations at the Microscopy and Microanalysis 2021 Virtual
Meeting, Symposium B11.3 - Frontiers in Fluorescence Lifetime and Super-resolution
Imaging of Biological Structures and Dynamics.
Congratulations, Tingting, on being designated a 2021 M&M Student
Scholar!
Dr. Meikun Shen, formerly in the Sadtler group, has published another
study on surface heterogeniety and charge-carrier separation in semiconductor photocatalysts. It
appears in J. Am. Chem. Soc. Congratulations!
“Single-Molecule Colocalization of Redox Reactions on Semiconductor Photocatalysts
Connects Surface Heterogeneity and Charge-Carrier Separation in Bismuth Oxybromide” [Article]
Matt was designated as an OSA Senior Member. Congratulations!
Matt presented at the 2021
OSA Imaging and Applied Optics Congress:
Matt spoke at the “Probing
Chemical Reactions by Single-Molecule Spectroscopy” virtual conference. It was a
fascinating day of single-molecule research! Thank you Suzanne and Randy for organizing!
The lab extends a (belated) welcome to Weiyan, Ziyi, and Makaiya! Weiyan Zhou has joined our lab
for her PhD studies. Ziyi Hu and Makaiya Smith are working with us on summer research projects.
Learn more about them.
After more than a year apart, the group celebrated Hesam's and Tianben's accomplishments.
Congratulations on earning your PhDs!
We also wished Jin farewell as he begins his new position at the National Center for Nanoscience
and Technology in Beijing. Thank you for making us all better chemists!
Congratulations to Tingting on receiving the department's Outstanding Graduate Student
Assistant to the Instructor (AI) Award! Tingting received this award during the McKelvey Engineering Honor Ceremony
held on April 21, 2021.
Oumeng and Matt presented talks at Focus on Microscopy
2021 online, March 28-31:
- “Measuring Single-Molecule Orientations Using a Radially and Azimuthally Polarized
Epifluorescence Microscope”
- “Visualizing Membrane Composition and Amyloid Aggregate Organization Using
Single-Molecule 3D Orientation Imaging”
The lab welcomes Brian Sun, who has received a Summer Undergraduate Research Award to work with us this summer on amyloid imaging. Congratulations Brian!
Oumeng's two-part series exploring orientation-localization microscopy has been accepted to
J. Opt. Soc. A!
- “Single-molecule orientation localization microscopy I: fundamental limits” [arXiv.org, Article]
- “Single-molecule orientation localization microscopy II: a performance comparison”
[arXiv.org, Article]
And, the SMOLM II paper has been selected as an “Editors'
Pick”! Congratulations, Oumeng!
Matt gave an invited seminar “Toward Visualizing
the Dynamic Organization of Amyloid Aggregates using Single-Molecule Orientation Localization
Microscopy” at the Knight Alzheimer
Disease Research Center at Washington University.
2020
Hesam's development and characterization of Wasserstein Induced Flux for certifying the
statistical confidence of localization microscopy datasets is now online in Nature
Communications! Congratulations, Hesam!
Read the press coverage: The
Source - Washington University, EurekAlert!
Read the article: “Quantifying
accuracy and heterogeneity in single-molecule super-resolution microscopy”
Matt has been honored with the 2020 “Excellence in Teaching” award from Emerson Electric Co.! Each year, honorees are chosen by the deans of their schools and recognized by the Center for Teaching and Learning.
Tianben, Jin, and Oumeng presented their recent work at
S3IC
2020: Single-Molecule Sensors and NanoSystems. Check out their presentations here:
Congratulations to Oumeng, whose patent covering the tri-spot PSF has been granted!
Update: The paper has been selected by the editors as a “Hot Paper” on
Nanoscale Sensors. Congratulations, Jin!
Read the press coverage: The
Source - Washington University, The Analytical
Scientist, EurekAlert!
Read the article: “Single-molecule 3D
orientation imaging reveals nanoscale compositional heterogeneity in lipid
membranes”
, updated 8.3.20
Congratulations to Dr. Hesam Mazidi, Dr. Tianben Ding, and Jack Hyde on successfully defending their dissertations! It's been a pleasure having you in the lab!
Oumeng's work on deriving the quantum limits of measuring molecular
orientation is now online in Phys. Rev. Research. Congratulations, Oumeng!
“Quantum limits for precisely estimating the orientation and wobble of dipole
emitters” [Article]
Meikun in the Sadtler group has published another study on the
photocatalytic activity of semiconductor nanoplates in J. Phys. Chem. Lett.
Congratulations!
“Competing Activation and Deactivation Mechanisms in Photodoped Bismuth Oxybromide
Nanoplates Probed by Single-Molecule Fluorescence Imaging” [Article]
Tianben and Tingting's work on using super-resolution single-molecule
orientation localization microscopy to study amyloid aggregates is now online in
Optica. Congratulations!
See: single-molecule orientation
localization microscopy in action
Read the press coverage: OSA
news release, The
Source - Washington University, EurekAlert!, Photonics
Media
Read the article: “Single-molecule orientation localization
microscopy for resolving structural heterogeneities between amyloid fibrils”
We welcome Tristan Carlson and James Cevasco to the lab!
Congratulations to Max on his Summer Undergraduate
Research Award! Max will be working with Jack on our ultrafast camera collaboration with the
Buckley lab in Physics.
Matt has been recognized with the 2019-2020 Outstanding Teaching Award from the Department of Electrical and Systems Engineering! Matt received the award as part of the ESE Awards and Recognition Ceremony on May 8, 2020.
Congratulations to Jack for winning the Rick Grodsky ESE Award for Technical
Achievement! Jack received the award as part of the ESE Awards and Recognition Ceremony on May 8,
2020.
Matt and Oumeng presented at the Computational
Optical Imaging workshop at the IEEE ISBI 2020 virtual conference.
Our collaborative work on imaging photocatalytic activity, jointly
led by Tianben and Meikun in the Sadtler group in the Department of Chemistry, is now online in
ACS Catalysis. Congratulations, all!
“Nanoscale Colocalization of Fluorogenic Probes Reveals Role of Oxygen Vacancies in the
Photocatalytic Activity of Tungsten Oxide Nanowires” [Open Scholarship, Article]
Press coverage: The
Source - Washington University
Jin and Tianben presented their recent work at the 64th Annual Meeting of the Biophysical Society in San Diego.
Hesam and Tingting presented their recent work in the
“Single
Molecule Spectroscopy and Superresolution Imaging XIII” session at SPIE Photonics
West in San Francisco. Read about their work here:
“Measuring localization confidence for quantifying accuracy and heterogeneity in
single-molecule super-resolution microscopy” [Open Scholarship, Article]
“A computationally-efficient bound for the variance of measuring the orientation of single
molecules” [Open Scholarship, Article]
Hesam's work on
“Quantifying Localization Accuracy in Single-Molecule Super-Resolution Microscopy”
was presented in the “New Frontiers in Single Molecule Microscopy” session at QBI 2020 in Oxford, UK.
2019
Matt gave an invited talk
in the “Computational Modeling in High-Resolution Imaging” session at the 25th Solvay Conference
on Chemistry “Computational Modeling: From Chemistry to Materials to
Biology” in Brussels, Belgium.
Oumeng's paper entitled “Fundamental limits on measuring the
rotational constraint of single molecules using fluorescence microscopy” has been
published in Physical Review Letters. Congratulations! [arXiv.org, Article]
Press coverage: The
Source - Washington University
Oumeng's and Hesam's works were presented at the OSA Imaging
and Applied Optics Congress on June 24-27, 2019, in Munich:
“Fundamental Limits on Imaging the
Orientational Dynamics of Dipole-Like Emitters”
“Single-Molecule Super-Resolution
Imaging of Molecular Orientation using a Tri-Spot Point Spread Function”
The lab welcomes James Jusuf and Tara Porter to St. Louis! Both James
and Tara were awarded Summer Undergraduate Research Fellowships from Caltech to lead their own
research projects in our group.
Matt gave an invited talk
at Washington University's Imaging
Sciences Pathway Retreat 2019 entitled “Single Molecules and Point Spread Function
Engineering for Visualizing Amyloid Protein Dynamics at the Nanoscale.” The group also
presented several posters at the event!
Matt gave an invited talk at the 5th Annual Meeting
of the Biophysical Society of Canada at the University of Toronto, Mississauga.
The group threw a farewell
board game party for Eshan, Kevin, and Weiran. Thank you all for being wonderful colleagues, and
we wish you the best in your next endeavors!
Eshan presented his and Hesam's work on DNA imaging at
the IEEE International Symposium on Biomedical
Imaging (ISBI) on Apr. 8-11, 2019, in Venice.
“Dense Super-Resolution Imaging of Molecular Orientation Via Joint Sparse Basis
Deconvolution and Spatial Pooling” [arXiv.org, Article]
Oumeng and Kevin presented their work at the OSA Biophotonics
Congress: Optics in the Life Sciences meeting on Apr. 14-17, 2019, in Tuscon.
“Measuring
Rotational Dynamics with High Accuracy and Precision Using a Tri-spot Point Spread
Function”
“Long-Term
Super-Resolution Imaging of Amyloid Structures Using Transient Binding of Thioflavin
T” [OSA
News Release]
Our lab has begun working with a multi-university team to build functional living electronics, called Livtronics, as part of the Office of Naval Research-funded Multidisciplinary University Research Initiative (MURI) Program. Our aim is to build new fluorescence imaging technologies to visualize electron transport within living systems. Read more about it here. [McKelvey School of Engineering news]
Tianben and Oumeng presented their work at Photonics
West. See it here:
“Long-term, super-resolution imaging of
amyloid structures using transient amyloid binding microscopy”
“Fundamental limits of measuring
single-molecule rotational mobility”
Tingting Wu, a PhD student in our Imaging Science
PhD program, has joined the Lew Lab. Welcome, Tingting!
2018
Jack presented his summer
research project at WashU's Fall 2018 Undergraduate Research Symposium.
Kevin's and Tianben's article on super-resolution transient amyloid binding (TAB) microscopy is
a featured cover article at
ChemBioChem. Congratulations to the entire team! Read it here:
“Super-Resolution Imaging of Amyloid
Structures over Extended Times Using Transient Binding of Single Thioflavin T
Molecules” [Open Scholarship]
Press coverage: The
Source - Washington University, NSF
Science360, Futurity, EurekAlert!
Henry Cohen, who is studying for an MS degree in
Biomedical Engineering, has joined the Lew Lab and received a Master's Fellowship. Welcome,
Henry!
Hesam's article on the characteristics of structural bias in super-resolution microscopy and how
to minimize it using our RoSE algorithm is now online at Scientific Reports.
Congratulations! Read it here:
“Minimizing
Structural Bias in Single-Molecule Super-Resolution Microscopy”
Weiran Wang, who is studying for an MS degree in
Electrical Engineering, has joined the Lew Lab and received a Master's Fellowship. Welcome,
Weiran!
Our collaborative work
with Dr. Greg Lanza on imaging the intracellular fate of lipid prodrugs is a featured cover article in Precision
Nanomedicine. Read it here:
“Cellular
Trafficking of Sn-2 Phosphatidylcholine Prodrugs Studied with Fluorescence Lifetime Imaging
and Super-resolution Microscopy”
Oumeng's
article on the Tri-spot point spread function is now online at Applied Physics Letters.
Congratulations Oumeng! Read it here:
“Imaging the three-dimensional orientation and
rotational mobility of fluorescent emitters using the Tri-spot point spread
function”
[Open
Scholarship]
Matt gave an invited Stanford
Optical Society seminar entitled “Computational
Optics for Multidimensional Nanoscale Imaging of Single Fluorescent Molecules.”
Jack Hyde, who is majoring in Electrical Engineering,
has joined the Lew Lab. He has received a Summer Undergraduate Research Award from the Office of
Undergraduate Research. Welcome, Jack!
Kevin Spehar, who is majoring in Biomedical
Engineering, has joined the Lew Lab. Welcome, Kevin!
Hesam and Oumeng gave excellent presentations at SPIE
BiOS (Photonics West). See them here:
“A robust statistical estimation (RoSE)
algorithm jointly recovers the 3D location and intensity of single molecules accurately and
precisely”
“Measuring 3D molecular orientation and
rotational mobility using a Tri-spot point spread function”
2017
Matt has received a five-year, $1.6 million Maximizing Investigators'
Research Award from the National Institute of General Medical Sciences, part of the National
Institutes of Health. The project is entitled "Five-Dimensional
Single-Molecule Nanoscopy for Sensing and Imaging the Dynamic Functions of
Biomolecules." We are collaborating with Jan Bieschke at UCL's Institute of Prion Diseases. Congratulations
team! [The Source - Washington
University]
Eshan presented his summer
research project at the WashU Fall 2017 Undergraduate Research Symposium.
Hesam's and Oumeng's abstracts have been accepted for oral presentations in the "Single Molecule Spectroscopy and Superresolution Imaging XI" conference at SPIE BiOS (Photonics West). We're looking forward to showcasing our work in San Francisco in 2018! [Conference program]
Eshan King, who is majoring in Biomedical
Engineering and Applied Mathematics, has joined the Lew Lab. He has received a Summer
Undergraduate Research Award from the Office of Undergraduate Research. Welcome, Eshan!
We have received a Collaboration Initiation Grant from the School of Engineering & Applied Science to build a fluorescence-lifetime imaging nanoscope in collaboration with James Buckley in the Department of Physics. Congratulations team! [WashU Engineering News]
Oumeng has successfully defended his Master's thesis, "Measuring Molecular Orientation and Rotational Mobility Using a Tri-spot Point Spread Function." Congratulations Oumeng! [ESE MS Defense Announcement PDF]
Matt has received a five-year,
$500,000 CAREER Award from the National Science Foundation for the project entitled "CAREER: Nanoscale sensing
and imaging using computational single-molecule nanoscopy." Congratulations team!
[WashU
Engineering News, The Source -
Washington University]
2016
Dr. Jin Lu joined the Lew Lab. Welcome Jin!
Our joint project "Single-Molecule, Super-Resolution
Imaging of Reaction Sites in Mesoscale Semiconductor Photocatalysts" with Prof. Bryce Sadtler in the
Department of Chemistry has
been funded by the WashU International Center for Advanced Renewable Energy and
Sustainability (I-CARES)!
Matt
was awarded the Hiruma/Wagner Award at the 16th Conference of Peace through Mind/Brain
Science.
We imaged single fluorescent molecules for the first time! What beautiful blinking!
2015
Tianben Ding, a PhD student in Electrical and
Systems Engineering, joined the Lew Lab. Welcome, Tianben!
Matt won first place
in Optics and Photonics News's 10th annual After Image
photo contest!
Matt gave an invited talk at Laser Science 2015 entitled “Accurate 3D nanoscale imaging of dipole-like emitters.”
Lab construction is completed and
ready for equipment move-in!
Matt gave the first lecture of ESE 582/BME 5820, Fundamentals and Applications of Modern Optical Imaging, a new graduate course at Washington University.
Matt joined the the Department of Electrical and Systems Engineering at Washington University in St. Louis as an Assistant Professor.